The inhibition of respiration by glucose, fructose, and mannose in the Ehrlich mouse ascites tumor.
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چکیده
منابع مشابه
Metabolism of Ascites Tumor Cells. Ii. Inhibition of Respiration by Glycolyzable and Nonglycolyzable Sugars Phosphorylated by Hexokinase.
The effects of twelve monosaccharides on the oxygen uptake of Krebs-2 ascites carcinoma cells were determined during prolonged incubation. Seven sugars were shown to inhibit respiration. The incubation periods required to induce inhibition were inversely related to the maximum rate of phosphorylation of each sugar by tumor hexokinase. Of these inhibiting sugars, the nonglycolyzable were 2-deoxy...
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The aim of this study is to investigate the antitumor activity and possible molecular mechanism of Phenethyl isothiocyanate (PEITC) against Ehrlich ascites carcinoma in-vivo and in-vitro.In-vivo, ascetic fluid volume, body weight, serum malondialdehyde (MDA) level and total antioxidant capacity (TAC) were determined using Ehrlich ascites carcinoma (EAC) bearing mice. In-vitro, MTT assay was use...
متن کاملPhenethyl isothiocyanate Triggers Apoptosis, Combats Oxidative Stress and Inhibits Growth of Ehrlich Ascites Carcinoma Mouse Model
The aim of this study is to investigate the antitumor activity and possible molecular mechanism of Phenethyl isothiocyanate (PEITC) against Ehrlich ascites carcinoma in-vivo and in-vitro.In-vivo, ascetic fluid volume, body weight, serum malondialdehyde (MDA) level and total antioxidant capacity (TAC) were determined using Ehrlich ascites carcinoma (EAC) bearing mice. In-vitro, MTT assay was use...
متن کاملMetabolism of ascites tumor cells. I. Rate of glycolysis and competitive utilization of fructose, mannose, and glucose.
The effects of carbohydrates and other chemical agents on the glycolysis of ascites tumors have been under extensive investigation in this laboratory (21). As par t of the program, the three known glycolyzable sugars, D-glucose, D-mannose, and Dfructose, have been studied to help unravel some of the complex factors involved in the regulation of the rate of glycolysis in the intact cells. I t wa...
متن کاملAntitumor Activity of Prosopis glandulosa Torr. on Ehrlich Ascites Carcinoma (EAC) Tumor Bearing Mice
The antitumor activity of ethanol extract of Prosopis glandulosa Torr. (EPG) was evaluated against Ehrlich ascites carcinoma (EAC) tumor model in Swiss albino mice on dose dependent manner. The activity was assessed using survival time, average increase in body weight, hematological parameters and solid tumor volume. Oral administration of EPG at the dose of 100, 200 and 400 mg/Kg, significantl...
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عنوان ژورنال:
- Cancer research
دوره 16 4 شماره
صفحات -
تاریخ انتشار 1956